This document was downloaded from the Los Alamos HIV database on 5/3/00
http://www.hiv.lanl.gov/ALIGN_FILES/POL/1POLpaln.fmt
1995-1997 alignments
CONSENSUS-A FFRE.NLAFQQ?EAR?F............SSE..QTR?NSPTS???LWD?G?D?.?LP?..?E?GAER.. 37
92UG037 ----.------R---K-............---..---T-----SRD---E-R-..S--S...-A----.. 48
U455 ----.------G---E-............---..---A-----R.N---G-K-D..--...C-T----.. 47
CONSENSUS-B FFRE.dlafpqGkAref????????????sse..QtranSptrr.ElqVwgrdnnslS????EAGadr?? 48
SF2 ----.----L-------............---..----------.------GE-----....------.. 48
LAI ----.----L-------SSEQTRANSPTI---..----------.-------------....------.. 60
HXB2R ----.----L-------............---..----------.-----------P-....------.. 48
NL43 ----.------------............---..----------.-------------....------.. 48
NY5CG ----.------------............---..----------.-------------....------.. 48
LW123 ----.----L-------............---..----------.-----------P-....------.. 48
MN ----.----L----.--............---..-N--------.-------------EAGE---D--.. 51
JRCSF ----.----L-------............P--..----------.--------S----EAGA------.. 52
JRFL ----.----L-------............---..---------K.--------S----....------.. 48
OYI ----.------------............---..--------S-.--R--------P-....------.. 48
CAM1 ----.N------E----............---..----------.-------E-----....------.. 48
HAN ----.-------E--K-............---..----------.------S.-S---....------.. 47
D31 ----.----L-------............--A..----------.--------S----....------.. 48
RF ----.N----------L............---..----------.---------.---....---E--.. 47
YU2 ----.----------K-............---..-------I--.-R---R-------....------.. 48
BCSG3C ----.------------............---..------S---.------G----P-....----G-.. 48
P896 ----.N-----------............---..----------.------G------....------.. 48
3202A12 ----.------------............---..----------.-------------....----EG.. 48
3202A21 ----.------------............---..----------.-------------....----EG.. 48
MANC ----.---L--------............---..---------G.-----------C-....---T--.. 48
TH475A ----.----L-------............---..----------.-----------P-....------.. 48
JH31 ----.----L-------............---..-------S-G.----------P--....----E-.. 48
C18MBC ----.N------E---LSSEQARTNSP..-PG..-AG-I--A--.------G------....------QG 60
ACH3202A12 ----.------------............---..----------.-------------....----EG.. 48
WR27 ----.NP---H------............P--..----I---S-.-------------....---T--.. 48
WEAU160 ----.--V--K------............---..---T------.----Q--------....----N-.. 48
CONSENSUS-C FFRE.?LAF?QG?AR????????????..??E?.Q?RANSPT?R.ELQV?G???N??S....EAG??R.. 31
92BRO25 ----.N---P--E--KS............SS-..-N------R-.----W-RDN-SL-....---DD-.. 48
ETH2220 ----.T---Q--K--EFPSEQTRANSP..TR-S.-T------T-.----R-S..-TF-....---AE-.. 57
CONSENSUS-D FFRE.dLAFPQGKAGEl............Sse..QTRANSPTSR.ELRVWGrDN.PLS....eTGAER.. 47
ELI ----.N-----------............-PK..----------.---------.---....K-----.. 47
Z2Z6 ----.------------............---..----------.---------.---....------.. 47
NDK ----.-----------F............---..----------.------G--.---....------.. 47
CONSENSUS-O FFR?.?LASGGHEARQL............CAE..TS?PISPT?......GGGSE.....GT?ES??E?G? 35
ANT70 ---Q.I-----------............---..--T-----D......-----.....--G--GT-R-P 44
MVP5180 ---E.V-----------............---..--V-----N......-----.....--R--ES-G-S 44
CONSENSUS-A FFRE.NLAFQQ?EAR?F............SSE..QTR?NSPTS???LWD?G?D?.?LP?..?E?GAER.. 37
A/G_IBNG ----.------G---K-............---..--GT--S--R.E---G-R-T.S-S....TA-T-G.. 47
A/E_93TH253 ----.------GK--E-............---..--GA--SA-R.K-G-G-.............----.. 39
A/E_CM240 ----.------GK-GE-............---..---A-----R.K-G-G-R-NGGRDNLLT-A----.. 52
A/E_90CR102 ----.------G---K-............P--..---A----NG.E-G-G-R-NLLPE.....A----.. 47
MAL ----.----P-GK--E-............P--..---A-----R.E-RVW-G-K.T-S....-T----.. 47
Z321B ----.------G---E-............---..---A----RR.E-R-ERG-N.L-S....-A-T-G.. 47
CONSENSUS-CPZ FFRE??????????R?L............CAE??????N??T?R.?L???????????....???????? 13
CPZGAB ----.RLAFPQREA-Q-............---..QNRT-GP-D-.E-WVPGGRE........EPGEERGR 46
CPZANT ----TDPHVVGVQT-E-............---GGSSGA-SS-H-.D-SGGAQEDSEGS............ 45
protease
\/ <- gag cds end
CONSENSUS-A QG?..???FSFPQITLWQRPLVTVKIGGQL??ALLDTGADDTVLEDINLPGKWKPK?IGGIGGFIKV?QY 97
92UG037 --P..EPT----------------------KK------------------------M----------K-- 116
U455 --...TDS----------------------IE------------------------I----------R-- 114
CONSENSUS-B QG...tVSfsfPQiTLwQRPlVtikigGQlKEALLDTGADDTVleeMnlPgrWKpKMiGGIGGFIKVrQY 115
SF2 --...----N--------------R--------------------------K------------------ 115
LAI --...----N-------------------------------------S---------------------- 127
HXB2R --...----N---V---------------------------------S---------------------- 115
NL43 --...--------------------------------------------------------------G-- 115
NY5CG --...----------------------------------------------------------------- 115
LW123 --...----N-------------------------------------S---------------------- 115
MN --...P--------------I-----------------------G-----R------------------- 118
JRCSF --...I---N-----------------------------------D-D---------------------- 119
JRFL --...N---N-----------------------------------D-D---------------------- 115
OYI --...----NL---------I------------------------------------------------- 115
CAM1 --...----------------------------------------------------------------- 115
HAN --...---L-L--------------------------------V---S---------------------- 114
D31 --...------------------------------------------S---------------------- 115
RF --...---------------I--V---------------------------K------------------ 114
YU2 --...----------------------------------------------------------------- 115
BCSG3C --...N--L------------------------------------------------------------- 115
P896 --...---L----------------V-------------------D-S---------------------- 115
3202A12 --...---L-L----------------------------------------------------------- 115
3202A21 --...---L-L----------------------------------------------------------- 115
MANC --...---L----T-------------------------------------------------------- 115
TH475A --...----N-------------------------------------S---------------------- 115
JH31 --...------------------L------------------------S-----x 100
C18MBC --...S---------------------------------------D-H---K---------------K-- 127
ACH3202A12 --...---L-L----------------------------------------------------------- 115
WR27 --...-----------C-----A------I-----------------S---------V------------ 115
WEAU160 --...A---N----------------E------------------D-----K------------------ 115
CONSENSUS-C QG....??LNFPQITLWQRPLV?IK?GGQLKEALLDTGADDTVLEEI?LPG?WKPKMIGGIGGFIKVRQY 91
92BRO25 --...TA.--------------N--V---------------------K---N------------------ 114
ETH2220 --.....S--------------T--I---------------------N---K------------------ 122
CONSENSUS-D QG...TVSFnfPQITLWQRPLVtIKIGGQLKEALLDTGADDTVLEEmNLPGKWKPKMIGGIGGFIKVRQY 114
ELI --...-----------------A----------------------------------------------- 114
Z2Z6 --...-----C----------------------------------------------------------- 114
NDK --...----S------------------------------------I----------------------- 114
CONSENSUS-O ?R...A???CLPQIPLWDRPIVTA?VGGHLCE?LLDTGADDTVLNNIQLEG?W?PKMIGGIGGFIKVKEY 94
ANT70 E-...-LSV---------------R-------V------------------K-K---------------- 111
MVP5180 G-...-VPI---------------K-------A------------------R-T---------------- 111
CONSENSUS-A QG?..???FSFPQITLWQRPLVTVKIGGQL??ALLDTGADDTVLEDINLPGKWKPK?IGGIGGFIKV?QY 97
A/G_IBNG --A..ISS-N--------------R-E---IE------------------------M----------R-- 115
A/E_93TH253 --T..SSS---------------I------KE------------------------M----------R-- 107
A/E_CM240 --T..SSS----------------------KE------------------------M----------K-- 120
A/E_90CR102 -ET..ASS-----------------V----KE------------------------M----------R-- 115
MAL --...IVS------------V---RV----KE-------------E----------M----------R-- 114
Z321B --T..IPS------------Ix 67
CONSENSUS-CPZ ???????S???P?I?LWQRP???V???GQ?C?ALLDTGADDTV?E?I?LQG?WKPK?IGGIGGFI?V?Q? 55
CPZGAB EQ...SI-TNL-Q-T-----LIP-KVE--L-E-----------I-R-Q---L----M--------K-K-F 113
CPZANT QGGGGTT-LVF-E-P-----MME-LIQ--K-Q-----------V-G-H---N----T--------S-Q-Y 115
protease \/ p66, p51
CONSENSUS-A DQILIEICGKK?IGTVLVGPTPVNIIGRNMLT?IGCTLNFPISPI?TVPVKLKP?MDGP??KQWPLTEEK 161
92UG037 -----------A--------------------L------------S--------G----RI--------- 186
U455 -----------T--------------------Q------------E--------E----KV--------- 184
CONSENSUS-B dqilieicghkaigtvlvgptpvniigrnlltqigctlnfpispietvpvklkpgmdgpkvkqWPLTEEK 185
SF2 ---PV----------------------------------------------------------------- 185
LAI ---------------------------------------------------------------------- 197
HXB2R ---------------------------------------------------------------------- 185
NL43 ---------------------------------------------------------------------- 185
NY5CG ---------------------------------------------------------------------- 185
LW123 ---------------------------------------------------------------------- 185
MN ---T-G---------------------------L------------------------------------ 188
JRCSF ---P-D------V--------------------------------------------------------- 189
JRFL ---------------------------------------------------------------------- 185
OYI ---------------------------------L------------------------------------ 185
CAM1 ---P------------------------------------------------------------------ 185
HAN ----V----------------------------------------------------------------- 184
D31 ---------------------------------------------------------------------- 185
RF ---------------------------------------------------------------------- 184
YU2 ---P------------------------------------------------------------------ 185
BCSG3C ---P------------------------------------------------------------------ 185
P896 E--D--------K--------------------------------------------------------- 185
RET7 ------------------------------ 30
VE1RT ------------------------------ 30
VE2RT ------------------------------ 30
VE3RT ------------------------------ 30
VE4RT ------------------------------ 30
VE5RT ------------------------------ 30
VE6RT ------------------------------ 30
VE7RT ------------------------------ 30
VE8RT ------------------------------ 30
HX330BC ------------------------------ 30
HX660BC ------------------------------ 30
HXBCRT ------------------------------ 30
PD165BC ------------------------------ 30
PD330BC ------------------------------ 30
PD495BC ------------------------------ 30
PD660BC ------------------------------ 30
PDBCRT ------------------------------ 30
3202A12 ---A------------------------------------------------------------------ 185
3202A21 ---P------------------------------------------------------------------ 185
MANC ---------------------------------------------------------------------- 185
NH51 $L------------------------------------------- 44
PFA330 ------------------------------ 30
PFA660 ------------------------------ 30
PFA660AZT0 ------------------------------ 30
TH475A ---------------------------------------------------------------------- 185
POLMA ...............................................................------- 7
C18MBC -E--V---------------------------------------------Q------------------- 197
ACH3202A12 ---A------------------------------------------------------------------ 185
PDBC ------------------------------ 30
WR27 ---P------------------------------------------------------------------ 185
RTPX ------------------------------ 30
POI17B --L------------------------------------ 39
WEAU160 --VP------------------------------------------------------------------ 185
CONSENSUS-C DQI?IEICGKKAIGTVLVGPTPVNIIGRNMLTQiGcTLNFPISPIETVPVKLKPGMDGPKVKQWpLTEEK 160
92BRO25 ---L-----------------------------L------------------------------L----- 184
IND8 ------------------------------------- 37
IND7 ------------------------------------- 37
IND6 ------------------------------------- 37
IND5 ------------------------------------- 37
IND4 L------------------------------------ 37
ETH2220 ---I-----------------------------L-R---------------------------------- 192
CONSENSUS-D DQIlIEICG?KAiGTVLVGPTPVNIIGRNLLTQIGCTLNFPISPIETVPVKLKPGMDGPKVKQWPLTEEK 183
ELI ---P-----Q------------------------------------------------------------ 184
Z2Z6 ---------H------------------------------------------------------------ 184
NDK ---------Y--M--------------------------------------------------------- 184
CONSENSUS-O ?NVTVE??G?EVQGTVLVGPTPVNI?GRNILTGLGCTLNFPISPIAPVPVKLKPGMDGPKVKQWPLS?EK 158
ANT70 D-----IE-R---------------I-----------------------------------------K-- 181
MVP5180 N-----VQ-K---------------L-----------------------------------------R-- 181
CONSENSUS-A DQILIEICGKK?IGTVLVGPTPVNIIGRNMLT?IGCTLNFPISPI?TVPVKLKP?MDGP??KQWPLTEEK 161
A/G_IBNG -----------A--------------------Q------------E--------G----KV--------- 185
A/E_93TH253 -----------A--------------------Q------------D--------G----KV--------- 177
A/E_CM240 -----------A--------------------Q------------D----T---G----KV--------- 190
A/E_90CR102 -----------A--------------------Q------------D----T---G----KV--------- 185
MAL -----------A---I----------------Q------------E--------G----RV--------- 184
CONSENSUS-CPZ ??V?I?I??R?V??TVL?GP?PVNIIGRN?L??LGCTL?FPIS??ETVPVKLK?GMDGP?VKQWPLS?EK 105
CPZGAB DN-H-E-EG-K-VG---V--T--------I-TQ-----V----SI--------P-----K-------A-- 183
CPZANT NK-P-Q-GD-T-LA---L--N--------V-CL-----N----KV--------E-----R-------K-- 185
| M41L D67N | | K70R
CONSENSUS-A IKALTEIC??ME?EG?ISKIGPENPYNTP?FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPH?AGL 225
92UG037 --------AD--R--R-------------I------------------------------------P--- 256
U455 --------NE--K--K-------------V------------------------------------T--- 254
CONSENSUS-B IKaLvEICTemEKeGKisKiGPENPYNTPvFAIKKKdstkWRKLvDFReLNkrTQDFweVQlGIPHPaGl 255
SF2 ---------------------------------------------------------------------- 255
LAI ---------------------------------------------------------------------- 267
HXB2R ---------------------------------------------------------------------- 255
NL43 ---------------------------------------------------------------------- 255
NY5CG ---------------------------------------------------------------------- 255
LW123 ---------------------------------------------------------------------- 255
MN ----I-----------------------------------------------K----------------- 258
JRCSF ---------------------------------------------------R------------------ 259
JRFL ----------------------------------------------------K----------------- 255
OYI --V-I--------------V-------------------------------------------------- 255
CAM1 ---------------------------------------------------------------------- 255
HAN ----I----------------------------------------------------------------- 254
D31 ---------------------------------------------------------------------- 255
RF ---------------------------------------------------------------------- 254
YU2 ---------------------------------------------------------------------- 255
BCSG3C ---------------------------------------------------------------------- 255
P896 ---------------------------------------------------------------------- 255
RET7 ---------------------------------------------------------S------------ 100
VE1RT ----T----K-------------------I---------------------------------------V 100
VE2RT ----------L----------------------------------------------------------- 100
VE3RT ---------------------------------------------------------------------- 100
VE4RT ----I-----L-----------------------------------------K----------------- 100
VE5RT ---------------------------------------------------------------------- 100
VE6RT ---------------------------------------------------------------------- 100
VE7RT ---------------------------------------------------------------------- 100
VE8RT ---------------------------------------------------------------------- 100
HX330BC ---------------------------------------------------------------------- 100
HX660BC ---------------------------------------------------------------------- 100
HXBCRT ---------------------------------------------------------------------- 100
PD165BC -------------------------------------------------------------I-------- 100
PD330BC ----------------------------------------------------------K----------- 100
PD495BC ----------------------------------------------------------K----------- 100
PD660BC ----------------------------------------------------------K----------- 100
PDBCRT ---------------------------------------------------------------------- 100
3202A12 ---------------------------------------------------------------------- 255
3202A21 ---------------------------------------------------------------------- 255
MANC ---------------------------------------------------------------------- 255
NH51 ------------------------------------------------G---K----------------- 114
PFA330 ---------------------------------------R----I------------------------- 100
PFA660 ----------L----------------------------R-----------------G------------ 100
PFA660AZT0 ----------L-------------------------NN-R-----------------S------------ 100
TH475A ---------------------------------------------------------------------- 255
POLMA ---------------------------------------------------------------------- 77
C18MBC -------------------------------------G----------D------------------S-- 267
ACH3202A12 ---------------------------------------------------------------------- 255
PDBC ---------------------------------------------------------------------- 100
WR27 ----------------VT---------------------------------------------------- 255
RTPX ----------L----------------------------------------------------------- 100
POI17B ----------L--D----------------------N-D------------------------------- 109
WEAU160 -------------------------------------------------------------------S-- 255
CONSENSUS-C IKALTAICdEMEkeGKItkIGPENPYNTPiFAiKKKDSTKWRKLVDFRELNKRTqdFWEVQLGIPHPAGL 230
92BRO25 ------------R----------------V------------------------$--------------- 253
IND8 --------E-----------------------L------------------------------------- 107
IND7 ---------------------------------------------------------------------- 107
IND6 --------------------------------L------------------------------------- 107
IND5 --------E-----------------------L----------------------N-------------- 107
IND4 -------------G---S---------------------------------------------------- 107
ETH2220 --------E---Q----SR----------V---------------------------------------- 262
CONSENSUS-D IKALTEICTeMEKEGKISRiGPENPYNTPIFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGL 253
ELI ---------D------------------------------------------------------------ 254
Z2Z6 -------------------V-------------------------------------------------- 254
NDK ---------------------------------------------------------------------- 254
CONSENSUS-O IEALTAICQEMEQEGKISRIGPENPYNTPIFAIKKKD?TKWRKLVDFRELNKRTQ?FWEVQLGIPHPGGL 226
ANT70 -------------------------------------G-----------------E-------------- 251
MVP5180 -------------------------------------S-----------------D-------------- 251
CONSENSUS-A IKALTEIC??ME?EG?ISKIGPENPYNTP?FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPH?AGL 225
A/G_IBNG -----D--TE--K--K-------------V------------------------------------P--- 255
A/E_93TH253 --------KE--E--K-------------V------------------------------------P--- 247
A/E_CM240 --------KE--E--K-------------V------------------------------------P--- 260
A/E_90CR102 --------KE--E--K-------------V------------------------------------P--- 255
MAL --------KD--K--K-L-----------V---------------N--------------------P--- 254
CONSENSUS-CPZ I?AL?EIC???E?E?KIS?IGP?NPYNTPIFAIKKKD??KWRKLVDFRELNKRTQDFWE?QLGIPHPAGL 163
CPZGAB -K--T---QEM-K-G---K---E--------------ST--------------------V---------- 253
CPZANT -E--K---DKL-A-N---R---D--------------TS--------------------I---------- 255
CONSENSUS-A KKKKSVTVLDVGDAYFSVPLDESFRKYTAFTIPS?NNETPG?RYQYNVLPQGWKGSP?IFQ?SMTKILEP 291
92UG037 ----------------------------------T------I---------------A---A-------- 326
U455 ----------------------------------I------V---------------S---S-------- 324
CONSENSUS-B KkkkSvTvLDVGDayFSvPLdedfRKYTaFTIPSinNEtPgiRYQYNVLPQGWKGspaIfqsSMtkiLEP 325
SF2 ---------------------K------------------------------------------------ 325
LAI ---------------------------------------------------------------------- 337
HXB2R ---------------------------------------------------------------------- 325
NL43 -Q-------------------K---------------------------------------C-------- 325
NY5CG -Q-------------------K---------------------------------------C-------- 325
LW123 ---------------------------------------------------------------------- 325
MN ---------------------K------------------------------------------------ 328
JRCSF ---------------------K------------------------------------------------ 329
JRFL --R------------------K------------------------------------------------ 325
OYI ---------------------K------------------------------------------------ 325
CAM1 ---------------------K------------T----------------------------------- 325
HAN ---------------------K------------------------------------------------ 324
D31 -----------------------------------------V---------------------------- 325
RF ---------------------KE-----------------R----------------------------- 324
YU2 --------------------H--------------------T-----------------------T---- 325
BCSG3C -------------R-------K------------------------------------------------ 325
P896 ---------------------------------------------------------------------- 325
RET7 --------------------HK------------T-----------------------------I----- 170
VE1RT ---------------------K------------V----------------------------------- 170
VE2RT ---------------------K------------V--------------------------C-------- 170
VE3RT ---------------------K------------------------------------------------ 170
VE4RT ---------------------K------------T----------------------------------- 170
VE5RT ---------------------KE--------------------------------------C-------- 170
VE6RT ---------------------KE------------------V-----------------S-C-------- 170
VE7RT ----------------------G----------------------------------------------- 170
VE8RT ----------------------------------T----------------------------------- 170
HX330BC -------------------------------------------------------A-------------- 170
HX660BC -------------------------------------------------------A-------------- 170
HXBCRT --R------------------------------------------------------------------- 170
PD165BC ----------------------S----------------------------------------------- 170
PD330BC ----------------------S----------------------------------------------- 170
PD495BC ----------------------S----------------------------------------------- 170
PD660BC ----------------------S----------------------------------------------- 170
PDBCRT ----------------------S----------------------------------------------- 170
3202A12 ---------------------K------------V--------------------------C-------- 325
3202A21 -----G-A-------------K------------V--------------------------C-------- 325
MANC --------------------Y-------V---------A--V---------------------------- 325
NH51 ---------------------KE---------------------------------S---------F--- 184
PFA330 ----------------------S----------------------------------------------- 170
PFA660 ---------------------------------------------------------------------- 170
PFA660AZT0 ------------------------------------------------------------H--------- 170
TH475A ---------------------------------------------------------------------- 325
POLMA ---------------------------------------------------------------------- 147
C18MBC ----------------------N------------------------------------------R---- 337
ACH3202A12 ---------------------K------------V--------------------------C-------- 325
PDBC ----------------------S----------------------------------------------- 170
WR27 --------------N------KEI----------TH---------------------T--P----Q---- 325
RTPX ---------------------K------------T----------------------------------- 170
POI17B -R-N-------------I---------------------------------------------------- 179
WEAU160 ---------------------------------------------------------------------- 325
CONSENSUS-C KKKKSVTVLDVGDAYFSVPLyEdFRKYTAFTIPSiNNETPGIRYQYNVLPQGWKgSPaIFQsSmtkILEP 300
92BRO25 --------------------D-G----------------------------------S-----T------ 323
IND8 ----------------------------------R--------------------------C-------- 177
IND7 -------------------------------------------------------------C-------- 177
IND6 ---------------------------------------------------------------------- 177
IND5 ----------------------------------R-------------------R--S---A-------- 177
IND4 -----------------------------------------------------------------R---- 177
ETH2220 --------------------D-G-----------T----------------------P------PQ---- 332
CONSENSUS-D KKKKSVTVLDVGDAYFSVPLDeDFRKYTAFTIpSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEP 323
ELI --------------------------------S------------------------------------- 324
Z2Z6 ---------------------K------------------------------------------------ 324
NDK ---------------------------------------------------------------------- 324
CONSENSUS-O KQ?QSVTVLDVGDAYFSCPLDPDFRKYTAFTIPSVNNETPG?RYQYNVLPQGWKGSPAIFQSSMTKILDP 294
ANT70 --K--------------------------------------I---------------------------- 321
MVP5180 --R--------------------------------------V---------------------------- 321
CONSENSUS-A KKKKSVTVLDVGDAYFSVPLDESFRKYTAFTIPS?NNETPG?RYQYNVLPQGWKGSP?IFQ?SMTKILEP 291
A/G_IBNG ---------------------KD-----------V------I---------------A---A-------- 325
A/E_93TH253 ----------------------------------I------I---------------A---S-------- 317
A/E_CM240 ----------------------------------I------I---------------A---S-------- 330
A/E_90CR102 ----------------------G-----------I------V---------------A---S-------- 325
MAL ----------------------D-----------I------I---------------A---S-------- 324
CONSENSUS-CPZ K?KKSVTVLDVGDAYFS?PLD?DFRKYTAFTIPS?NNETPG?RY?YNVLPQGWKGSP?IFQ?SMTKIL?P 224
CPZGAB -K---------------C---K------------I------V--Q------------S---S------E- 323
CPZANT -Q---------------I---Q------------V------I--C------------A---A------A- 325
polymerase motif
/<-->/ T215Y | | K219Q
CONSENSUS-A FRS??PDIVIYQYMDDLYVGSDLEIGQHR?KIEELR?HLL?WGF?TPDKKHQKEPPFLWMGYELHPDKWT 355
92UG037 ---KN------------------------T------E---K---T------------------------- 396
U455 ---QH------------------------A------A---S---I------------------------- 394
CONSENSUS-B FrkqnPdivIYQYMDDLYVGSdLEIgQHRtKIEeLRqhLlrwGftTPDkKHQKePPFLWMGYELHPDKWT 395
SF2 ---------------------------------------------------------------------- 395
LAI -------------------------------------------L-------------------------- 407
HXB2R -------------------------------------------L-------------------------- 395
NL43 ---------------------------------------------------------------------- 395
NY5CG ---------------------------------------------------------------------- 395
LW123 -------------------------------------------L-------------------------- 395
MN -----------------------------A------R--------------------------------- 398
JRCSF --------I-------------------------------K----------------------------- 399
JRFL --------I--------------------A---------------------------------------- 395
OYI ---------------------------------------------------------------------- 395
CAM1 -------------------------------------------L-------------------------- 395
HAN -------------------------E--------------K----------------------------- 394
D31 ---------------------------------------------------------------------- 395
RF -K----E----------------------I------E---K----------------------------- 394
YU2 -------L-------------------------------------------------------------- 395
BCSG3C ---------------------------------------------------------------------- 395
P896 -----------------------------A---D------K----------------------------- 395
RET7 ------E----------------------A----------K----------------------------- 240
VE1RT -------------------------E---------------G---------------------------- 240
VE2RT ----------------------------------------K---Y------------------------- 240
VE3RT ------------------------------------G---K--L-------------------------- 240
VE4RT ---------------------------------------------------------------------- 240
VE5RT ------G-----------------------------E--------------------------------- 240
VE6RT --------D-------------------------------K----------------------------- 240
VE7RT ----------------------------------------K----------------------------- 240
VE8RT ------G-----------------------------E--------------------------------- 240
HX330BC -K-------------------------------------------------------------------- 240
HX660BC -K-------------------------------------------------------------------- 240
HXBCRT -------------------------------------------L-------------------------- 240
PD165BC ----------------------------------------K----------------------------- 240
PD330BC ----------------------------------------K----------------------------- 240
PD495BC --------G-------------------------------K----------------------------- 240
PD660BC --------G-------------------------------K----------------------------- 240
PDBCRT ----------------------------------------K----------------------------- 240
3202A12 ---------------------------------------------------------------------- 395
3202A21 ---------------------------------------------------------------------- 395
MANC -------V-----------------------------Y--K----------------------------- 395
NH51 ----------------------------------------K----------------------------- 254
PFA330 ----------------------------------------K-------R--------------------- 240
PFA660 -------------------------------------------LY------------------------- 240
PFA660AZT0 ----S---------------------------------------Y------------------------- 240
TH475A ---------------------------------------------------------------------- 395
POLMA -------------------------------------------L-------------------------- 217
C18MBC --R--------------------------I----------K----------------------------- 407
ACH3202A12 ---------------------------------------------------------------------- 395
PDBC ----------------------------------------K----------------------------- 240
WR27 ---P--E--------------N------------------------------------------------ 395
RTPX ---------------------------------K-----W----Y------------------------- 240
POI17B ------------------------------------E--WK---Y------------------------- 249
WEAU160 -----------------------------------------------------D---------------- 395
CONSENSUS-C FRdrNPElvIYQYMDDLYVGSDLEIGQHRakIEELReHLLkWGFTTPDKKHQKEPPFLWMGYELHPDKWT 370
92BRO25 --AQ---II------------------------------------------------------------- 393
IND8 ---------------------------------------------------------------------- 247
IND7 ----------------------------------------R----------------------------- 247
IND6 -----------------------------G------Q---R----------------------------- 247
IND5 ----------------------------------------R----------------------------- 247
IND4 --AQ---I----------------------------G--------------------------------- 247
ETH2220 --AP---I----------------------P--------------------------------------- 402
CONSENSUS-D FRKQNPEiVIYQYMDDLYVGSDLEIGQHRTKIEeLREHLLRWGFTtPDKKHQKEPPFLWMGYELHPDKWT 393
ELI -------M-------------------------K-----------R------------------------ 394
Z2Z6 ---------------------------------------------------------------------- 394
NDK ---------------------------------------------------------------------- 394
CONSENSUS-O FR??NPE?EI?QY?DDLYVGSDLPL?EHRKR?ELLREHLYQWGFTTPDKKHQKEPPFLWMGYELHPDKWT 357
ANT70 --RD---L--C--M-----------T-----I-------------------------------------- 391
MVP5180 --KS---V--Y--I-----------A-----V-------------------------------------- 391
CONSENSUS-A FRS??PDIVIYQYMDDLYVGSDLEIGQHR?KIEELR?HLL?WGF?TPDKKHQKEPPFLWMGYELHPDKWT 355
A/G_IBNG --TKN-E----------------------A------G---K---T------------------------- 395
A/E_93TH253 --IKN-EM---------------------T------A---S---T----------------------R-- 387
A/E_CM240 --IKN-EM-----K---------------T------A---S---T----------------------R-- 400
A/E_90CR102 --ARN-E----------------------T-V-D--A---S---T----------------------R-- 395
MAL --TKN-E----------------------T------E---K---T------------------------- 394
CONSENSUS-CPZ FR?K?P???IYQYMDDLYVGSD?EI??HR???E?LRQHL??WG??TPDKKHQKEPPF?WMGYELHPDKWT 277
CPZGAB --E-N-DIT-------------L--DQ--KKV-E-----LK--FT------------L------------ 393
CPZANT --D-Y-AVE-------------M--TA--EMI-K-----QV--LE------------Q------------ 395
CONSENSUS-A VQPI?LPEK?SWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRG?KALTDIVTLTEEAELELAENREI. 421
92UG037 ----E----E-----------------------------------T-----------------------. 465
U455 ----Q----D-----------------------------------A-----------------------. 463
CONSENSUS-B VQPIvlPEkdsWTVNDIqKlVGKLNWaSQIYaGIkVkqLckLLrgtKALTEviplTeEAELElaenrei. 464
SF2 ----M----------------------------------------------------------------. 464
LAI -------------------------------P----R--------------------------------. 476
HXB2R -------------------------------P----R--------------------------------. 464
NL43 ------------------------------------R---------------V----------------. 464
NY5CG ------------------------------------R--------I------V----------------. 464
LW123 -------------------------------P----R--------------------------------. 464
MN ---------------------------------------------------------------------. 467
JRCSF --------------------------------------------------------K------------. 468
JRFL ---------------------------------------------------------------------. 464
OYI ----M--------------------------------N-------------------------------. 464
CAM1 ----M-----------------------------------------------V----------------. 464
HAN ---------------------------------------------P----------K------------. 463
D31 ----T-------------------------------R--------A----------K------------. 464
RF ----------------------------------------------------VQ--K------------. 463
YU2 ------------------------------------R--------------------------------. 464
BCSG3C -------------------------------S--------------------VT---------------. 464
P896 ----------------------------------------------------V----------------. 464
RET7 ---------------------------------------------P------V---K------------. 309
VE1RT ----M----E-----------------------------------------------------------. 309
VE2RT ---------------------------------------------------------------------. 309
VE3RT -----------------H-------------P--------R------------A--K------------. 309
VE4RT ---------E---------------------P---------------------S---------------. 309
VE5RT ----I--------------------------P-------------A-----------------------. 309
VE6RT --------E----------------------P-----------WAA------V----------------. 309
VE7RT ---------------------------------------------------------------------. 309
VE8RT ----E-------------------------------R--------------------------------. 309
HX330BC -------------------------------P----R--------------------------------. 309
HX660BC ----------R--------------------P----R--------------------------------. 309
HXBCRT -------------------------------P--R-R--------------------------------. 309
PD165BC ----M----------------------------------------------------------------. 309
PD330BC ----M----------------------------------------------------------------. 309
PD495BC ----M----------------------------------------------------------------. 309
PD660BC ----M----------------------------------------------------------------. 309
PDBCRT ----M----------------------------------------------------------------. 309
3202A12 ----M-------------------------------R--------------------------------. 464
3202A21 ------------------------------------RH-------------------------------. 464
MANC ----T--------------------------P-------------A----------K------------. 464
NH51 ---------------------------------------------P----------K------------. 323
PFA330 ----M----------------------------------------------------------------. 309
PFA660 -------------------------------P----R--------------------------------. 309
PFA660AZT0 -------------------V-----------P----R--------------------------------. 309
TH475A -------------------------------P----R--------------------------------. 464
POLMA -------------------------------P----R-------------------------WQKIGRF. 286
C18MBC -------------------------------P----R--------------------------------. 476
ACH3202A12 ----M-------------------------------R--------------------------------. 464
PDBC ----M----------------------------------------------------------------. 309
WR27 ----E---------------------P-------------------------V-----------G----. 464
RTPX ----------------------------------------------------V---K------------. 309
POI17B -----P---------------------------------x 289
WEAU160 ----K----E-----------------------------------------I--I--------------. 464
CONSENSUS-C VqPIQLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCkLLRGaKALTDIvpLTeEAELELAENREI. 439
92BRO25 ---------------------------------------------------------------------. 462
IND8 ----------------------------------------------------I----------------. 316
IND7 -R------------------------------------------------------K------------. 316
IND6 ----------------------------------------R----T----------K------------. 316
IND5 ---------------------------------------------T-----------------------. 316
IND4 ---------------------------------------------V-----------------------. 316
ETH2220 -----------------------------------------------------T---------------. 471
CONSENSUS-D VQsIkLPEKESWTVNDIQkLVgkLNWASQIYpGIKVrQLCKLLRGTKALTEViPLTEEAELELAENREI. 462
ELI ------------------N--ER----------------------------------------------. 463
Z2Z6 ---------------------------------------------------------------------. 463
NDK --P-N--------------------------A----K---------------V----------------. 463
CONSENSUS-O VQ?IQLP?K?VWTVNDIQKL?GKLNWASQIYQGIRV?ELCKLIRGTKSLTEVVPLS?EAELELEENRE?. 419
ANT70 --S----N-D----------I---------------R-------------------R-----------R. 460
MVP5180 --P----D-E----------V---------------K-------------------K-----------K. 460
CONSENSUS-A VQPI?LPEK?SWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRG?KALTDIVTLTEEAELELAENREI. 421
A/G_IBNG ---VE----D-------------------------I----R----A-------A---------------. 464
A/E_93TH253 ----E----D-----------------------------------T-------P---------E-----. 456
A/E_CM240 ----E----D-----------------------------------A-------P---------------. 469
A/E_90CR102 ----V----D--------------------------R--------A-----------------------. 464
MAL ----Q--D-E---------------------P-------------A-------P--A------------. 463
CONSENSUS-CPZ VQ?I?LPE???WTVNDIQKL?GKLNWASQIYPGIK?KQLC?LIRG?K?LTD?V??T?EAELEL?EN??I? 329
CPZGAB --P-Q---KEV---------I--------------I----K----T-K---V-PL-P------A--RE-. 462
CPZANT --K-K---PDD---------V--------------T----R----V-S---R-QM-R------E--KQ-K 465
CONSENSUS-A ..LKDPVHG?YYDPSKDL?AEIQKQGQDQW?YQIYQEPFKNLKTGKYARKRSAHTNDVKQL?EVVQKV?? 483
92UG037 ..-------A--------I-----------I------------------------------A------VM 533
U455 ..-------V--------V-----------T------------------------------T------ST 531
CONSENSUS-B ..lkePVHgvyyDPsKdLiaEiQKQgqgQWTYQIyQepfknLkTgKYarmrGaHTNDvkQltEAVQKiat 532
SF2 ..------E---------V------------------------------------------------VS- 532
LAI ..-----------------------------------------------T------------------T- 544
HXB2R ..------------------------------------------------------------------T- 532
NL43 ..------------------------------------------------K------------------- 532
NY5CG ..------------------------------------------------K------------------- 532
LW123 ..--------------------------------------------------T---------------T- 532
MN ..-------------------V------------------------------------------------ 535
JRCSF ..-----------------V--------------F--------------T-------------------N 536
JRFL ..-------------------L------------------I--------T-------------------N 532
OYI ..----------------V--L----------------------------------------------TQ 532
CAM1 ..-------------------L--------------------------K---T----------------- 532
HAN ..---------C------V-------E------------------------------I------------ 531
D31 ..------------------------------------------------------------------T- 532
RF ..-----------------------------------------------------------------V-- 531
YU2 ..-----------------------------------------------T-------------------- 532
BCSG3C ..------------------------------------------A----T------------------T- 532
P896 ..------------T------L----------------Y------------------------------- 532
RET7 ..------------------------------------------------------------------T- 377
VE1RT ..------------------------D----------------------T--T----------------- 377
VE2RT ..------------T-------------------------------------T----------------- 377
VE3RT ..--------------------------------------------------V-----R--V------TI 377
VE4RT ..-----------------------------------------------------------------V-- 377
VE5RT ..-------------------------D---------------------T-------------------- 377
VE6RT ..-------------------V----E--------------------T-S--T----------------- 377
VE7RT ..------------T------------------------------------------------------- 377
VE8RT ..------------T---V-------H----------------------------------------V-- 377
HX330BC ..------------------------------------------------------------------T- 377
HX660BC ..------------------------------------------------------------------T- 377
HXBCRT ..----------------------------------------R-------------------------T- 377
PD165BC ..----------------V--L----------------------------K------------------I 377
PD330BC ..----------------V--L----------------------------K------------------I 377
PD495BC ..----------------V--L----------------------------K------------------I 377
PD660BC ..----------------V--L----------------------------K------------------I 377
PDBCRT ..----------------V--L----------------------------K------------------I 377
3202A12 ..-------A--------V--------------------------------------------------Q 532
3202A21 ..--------------E---------------------------------------------------T- 532
MANC ..--V-------------T--------------------RS-------K---T--------------VT- 532
NH51 ..------------------------------------------------------------------V- 391
PFA330 ..--------F----- 323
PFA660 ..------------------------------------------------------------------T- 377
PFA660AZT0 ..------------------------------------------------------------------T- 377
TH475A ..------------------------------------------------------------------T- 532
POLMA ...$ 286
C18MBC ..-R---------------------E----------DQ-----------L----------FP-------- 544
ACH3202A12 ..-------A--------V--------------------------------------------------Q 532
PDBC ..----------------V--L----------------------------K------------------I 377
WR27 ..----------------V--L-----------------I---------T-------------------- 532
RTPX ..--------------P----L------------------------------V----------------- 377
WEAU160 ..-------------------L---------------------------V------------------T- 532
CONSENSUS-C ..LkEPVHGVyYDPSKDLIAEIQKQGqdQWTyQiYQEPFKNLKTGKyArm?TAHTNDV?QLT??VQKIAL 503
92BRO25 ..-------------------------N--------------------K-R-------R---EA------ 530
IND8 ..------------------------------------------------ 364
IND7 ..------------------------------------------------ 364
IND6 ..------------------------------------------------ 364
IND5 ..-R---------------------------------------------- 364
IND4 ..----------------------------------------------K- 364
ETH2220 ..--------F---------------N----F-F------------F-KRG-------K---AV------ 539
CONSENSUS-D ..LKEPVHGVYYDPSKDLIAEiQKQGhGQWTYQIYQEPFKNLKTGKYARmRGAHTNDVKQLaEaVQkIsT 530
ELI ..----------------------------------------------------------------R--- 531
Z2Z6 ..-------------------------------------------------------------V------ 531
NDK ..-------------------L----D----------------------T-----------T------A- 531
CONSENSUS-O ..LK?PVHGVYYQPDKDLWV?IQK?G??QWTYQ?YQ?EHKNLKTGKY?RQKASHTNDIRQLAEV?QKVSQ 478
ANT70 ..--Q---------------N---Q-GE-----I--E----------T----------------I----- 528
MVP5180 ..--E---------------S---H-EG-----V--D----------A----------------V----- 528
CONSENSUS-A ..LKDPVHG?YYDPSKDL?AEIQKQGQDQW?YQIYQEPFKNLKTGKYARKRSAHTNDVKQL?EVVQKV?? 483
A/G_IBNG ..--E----V----T---V--L--------T-----------------K------------T------AM 532
A/E_93TH253 ..-RI----V--------V--V--------T----------------S----------R--T-----IAT 524
A/E_CM240 ..--T----V--------V--V--------T------------------RG-------R--T------AT 537
A/E_90CR102 ..--T----V--------V-----------T---------------------------R--A------AT 532
MAL ..--E----V--------I--------G--T------QY----------IK----------T-A---IAQ 531
CONSENSUS-CPZ ????????G?YY?P???L?A?IQKQG??QWTYQI?Q???K?LK?GKYAR????HTN??RQLA??VQKI?? 366
CPZGAB ..VSTPVH-V--D-DKE-I-E-----NC------F-EPH-N--T-----QRSA---DI----EA----AT 530
CPZANT KKLQQKIE-Y--Q-GLP-K-T-----SG------Y-NEG-L--A-----PTGT---EV----GV----GL 535
p51 \/
CONSENSUS-A ESIVIWGK?PKF?LPIQKETWE?WWM?YWQAT?IPEWEFVNTPPLVKLWYQLEKDPIAGAETFYVDGAAN 548
92UG037 --------T---K---------T---D-----$------------------------------------- 602
U455 --------I---R---------A---E-----W------------------------------------- 601
CONSENSUS-B EsIvIWGKtPKfklpIQKETWe?wWteYwqATWIPEWEfVNTPPLVKLWYQLEkePIvGaETFYVDGAAn 601
SF2 --------I-------------A--M-------------------------------------------- 602
LAI ----------------------T----------------------------------------------S 614
HXB2R ----------------------T----------------------------------------------- 602
NL43 ----------------------A----------------------------------I------------ 602
NY5CG ----------------------A----------------------------------I------------ 602
LW123 ----------------------T----------------------------------------------- 602
MN ------------R---------T-----T$--------V------------------------------- 604
JRCSF --------I-------------T----------------------------------------------- 606
JRFL --------I-------------T----------------------------------------------- 602
OYI ----------------------A-------------------------------D--------------- 602
CAM1 ---------------------DA--ID------------------------------------------- 602
HAN -G----------R---------A----------------------------------------------- 601
D31 ----------------------A------------------------------T---------------- 602
RF ----------------------A----------------------------------I------------ 601
YU2 ----------------------T----------------------------------I------------ 602
BCSG3C -C-I--------R---------T----------------------------------E------------ 602
P896 ------------N.#-------A---D------------------------------------------- 600
RET7 --------I-------------T--------------------------------- 433
VE1RT -G--------------------T-------------------------------D--------------- 447
VE2RT ----------------------T----------------------------------------------- 447
VE3RT ------------R---------T----------------------------------------------- 447
VE4RT ------------R---------A------------------------------------V---------- 447
VE5RT ----------------------T----------------------------------I-----------S 447
VE6RT ----------------------T----------------------------------I-----------S 447
VE7RT ------------R---------T----------------------------------A------------ 447
VE8RT --------I-------------A--M-------------------------------------------- 447
HX330BC ----------------------T----------------------------------------------S 447
HX660BC ----------------------T----------------------------------------------S 447
HXBCRT ----------------------T----------------------------------------------- 447
PD165BC ------------R---------A--M-------------------------------------------- 447
PD330BC ------------R---------A--M-------------------------------------------- 447
PD495BC ------------R---------A--M-------------------------------------------- 447
PD660BC ------------R---------A--M-------------------------------------------- 447
PDBCRT ------------R---------A--M-------------------------------------------- 447
3202A12 ----------------------A----------------------------------------------- 602
3202A21 ----------------------A----------------------------------------------- 602
MANC ---I----I------------DA----------------------------------------------- 602
NH51 ----------------------T-----G------------- 433
PFA660 --------A-------------T----------------------------------------------- 447
PFA660AZT0 ----------------------T----------------------------------------------- 447
TH475A ----------------------T----------------------------------------------- 602
C18MBC ------------R--------DA----------------------------------I------------ 614
ACH3202A12 ----------------------A----------------------------------------------- 602
PDBC ------------R---------A--M-------------------------------------------- 447
WR27 -----------YI---------SR--------------S------------------------------S 602
RTPX ----------------------A------------------------------N---A------------ 447
WEAU160 ----------------------T----------------------------------------------- 602
CONSENSUS-C ESI?IWGKTPKFRLPIQKETWEAWWTDYWQAT?IPEWEFVNTPPLVKLWYQLEKEPIAG?ETFYVDGAAN 570
92BRO25 ---I----------------------------$--------------------------A---------- 599
ETH2220 ---V----------------------------W--------------------------V---------- 609
CONSENSUS-D ESIVIWGkTPKFrLPIQKETWETWW?EYWQATWIPEWEFVNTPPLVKLWYQLEKEPIIGAETFYVDGAAN 599
ELI -------R-----------------A-------------------------------------------- 601
Z2Z6 -------------------------V-------------------------------------------- 601
NDK ------------K------------I-------------------------------------------- 601
CONSENSUS-O E?I?IWGKLPKF?LPVTRETWETWWA?YWQATWIPEWEFVSTPPLIKLWY?LE?EPI?GAET?YVDGAAN 540
ANT70 -S-I--------K-------------D-----------------------R--S---M----Y------- 598
MVP5180 -A-V--------R-------------E-----------------------Q--T---V----F------- 598
CONSENSUS-A ESIVIWGK?PKF?LPIQKETWE?WWM?YWQAT?IPEWEFVNTPPLVKLWYQLEKDPIAGAETFYVDGAAN 548
A/G_IBNG --------T---R----R----T---E-----W------------------------V------------ 602
A/E_93TH253 --------T---R----R----T---E-----W------------------------V-----------S 594
A/E_CM240 --------T---R----R----T---E-----W------------------------V-----------S 607
A/E_90CR102 --------T---R----R----T---E-----W------------------------M-----------S 602
MAL --------T---R---------A--TE-----W--------------------TE--V------------ 601
CONSENSUS-CPZ ESIVIWG??PKF?LP???E?W?AWW??YWQATWIPEWEF?NTPPL??LWY?L???PIP???T?YVDGAAN 415
CPZGAB -------KT---R--VQK-S-E---AE------------I-----VK---S-ETE---TTD-Y------- 600
CPZANT -------EV---Q--ITR-T-D---SD------------V-----IR---N-LAD---EAE-F------- 605
CONSENSUS-A RETKLGKAGYVTDRGRQKVVSLTETTNQKTELHAIHLALQDSGSEVNIVTDSQYALGIIQAQPDRSESE? 617
92UG037 ---------------------------------------------------------------------L 672
U455 ---------------------------------------------------------------------I 671
CONSENSUS-B reTklGkAGYVTdrGRQkVvsltdTTNQkTeLqAIhLALQDSGlEVNIVtDSQYAlGIIQAQPDkSESEl 671
SF2 ---------------------IA----------------------------------------------- 672
LAI ------------N-------T------------------------------------------------- 684
HXB2R ------------N-------T--------------Y----------------------------Q----- 672
NL43 --------------------P------------------------------------------------- 672
NY5CG --------------------P------------------------------------------------- 672
LW123 ------------NK------P--N-----------Y---------------------------------- 672
MN ----K-------N--------------------------------------------------------- 674
JRCSF ------------S--------------------------------------------------------- 676
JRFL ------------N--------------------------------------------------------- 672
OYI ---------------------------------------------------------------------- 672
CAM1 ---R----------------P--------------Y---------------------------------- 672
HAN ----------------------N----------------------------------------------- 671
D31 -------------------------------------------------S-----I-------------- 672
RF ---------------------------------------------------------------------- 671
YU2 ------------NK---------------------Y----------------------------R----- 672
BCSG3C ------------NK------T-----------E------------------------------------- 672
P896 -D--S-----------------A----------------------------------------------- 670
VE1RT ---------------------V--------K------------S-------------------------- 517
VE2RT ----S-------NK---------------------Y---------------------------------- 517
VE3RT ----------------------------------------------------------------I----- 517
VE4RT ------------N--------IA--------------------P-------------------------I 517
VE5RT --------------------P------------------------------------------------- 517
VE6RT -------------K-------I------------------------------------------------ 517
VE7RT ------R-----NK------T-------R--------------S-------------------------I 517
VE8RT -----------------------------------Q---------------------------------I 517
HX330BC ------------N-------T------------------------------------------------- 517
HX660BC ------------N-------T------------------------------------------------- 517
HXBCRT ------------N-------T--------------Y----------------------------Q----- 517
PD165BC -------------K-------I------------------------------------------------ 517
PD330BC -------------K-------I------------------------------------------------ 517
PD495BC -------------K-------I------------------------------------------------ 517
PD660BC -------------K-------I------------------------------------------------ 517
PDBCRT -------------K-------I------------------------------------------------ 517
3202A12 ----------------------N------------N---------------------------------- 672
3202A21 ----------------------N------------N---------------------------------- 672
MANC -------------------I-----------------------------S-------------------- 672
PFA660 ------------N------AT--------------Y----------------------------Q----- 517
PFA660AZT0 ------------N-------T--------------Y----------------------------Q----- 517
TH475A ------------N-------T--------------Y---------------------------------- 672
C18MBC ---------------------------------------------------------------------I 684
ACH3202A12 ----------------------N------------N---------------------------------- 672
PDBC -------------K-------I------------------------------------------------ 517
WR27 ----------------------N----------------------------------------------- 672
RTPX ------------N-------P----------------------S-------------------------- 517
WEAU160 K-----------N----R----------------------------------------------Q----- 672
CONSENSUS-C RE?K?GKAGYVTDRGRQKIVS?TETTNQKTELQAIQLALQDSGSEVNIVTDSQYALGII?AQPDKSESE? 635
92BRO25 --I-M----------------I-------------------------------------Q---------L 669
ETH2220 --T-I----------------L-------------------------------------L---------I 679
CONSENSUS-D RETKLGKAGYVTDRGRQKVVPfTDTTNQKTELQAINLALQDSGLEVNIVTDSQYALGIIQAQPDKSESEL 669
ELI ---------------------L------------------------------------------------ 671
Z2Z6 ---------------------------------------------------------------------- 671
NDK ---------------------------------------------------------------------- 671
CONSENSUS-O R?TKLGKAGYVTEQGKQ?IIKL?ETTNQKAELMA?L?ALQDSKE?VNIVTDSQY?LG?ISSQPTQS?SPI 601
ANT70 -E---------------K----D-----------I-L-------T---------A--V--------E--- 668
MVP5180 -N---------------N----E-----------V-I-------Q---------V--I--------D--- 668
CONSENSUS-A RETKLGKAGYVTDRGRQKVVSLTETTNQKTELHAIHLALQDSGSEVNIVTDSQYALGIIQAQPDRSESE? 617
A/G_IBNG ----I----------------------------------------------------------------L 672
A/E_93TH253 -------------------I-------------------------------------------------V 664
A/E_CM240 ---------------------------------------------------------------------V 677
A/E_90CR102 ----Q--------------------------------------P------------------------DI 672
MAL ----K---------------------------Q-------------------------------K----I 671
CONSENSUS-CPZ R????GKAGYVTD?G??????L??TTNQQAEL?A?L?AL?DS???VNIVTDSQY?LG??Q??PD?SES?L 458
CPZGAB -ETKT--------K-KQKIIS-EN--------K-L-L--Q--DQQ---------V--II-SQ--H---E- 670
CPZANT -NSQL--------R-RSRVKH-QK--------Q-I-M--E--TGP---------A--VL-GT--Q---P- 675
CONSENSUS-A VNQIIEKLIEK?KVYLSWVPAHKGIGGNEQVDKLVSSGIRKVLFLDGIDKAQE?HE?YH?NWRAMASDFN 683
92UG037 -----------D-----------------------------------------E--R--S---------- 742
U455 -----------E-----------------------------------------D--K--C---------- 741
CONSENSUS-B VsQIIEqLIKKEKvYLaWVPAHKGIGGNEQVDkLVsaGiRkvLFldGIDkAQeeHEKYHsNWrAMAsdFN 741
SF2 ---------------------------------------------N------------------------ 742
LAI -N--------------------------------------------------D----------------- 754
HXB2R -N--------------------------------------------------D----------------- 742
NL43 --------------------------------G------------------------------------- 742
NY5CG ---------------------------------------------------------------------- 742
LW123 -N---------------------------------------I----------D----------------- 742
MN -----------------------------------------------------D---------------- 744
JRCSF -----------------------------------------------------D---------------- 746
JRFL -----------------------------------------------------D--------K------- 742
OYI ---------------------------------------------------------------------- 742
CAM1 ------E--------------------------------------------------------------- 742
HAN -----------------------------------------------------D------------N--- 741
D31 ----------------T-----------------------------------D----------------- 742
RF --------------------------------R---T---------------D----------------- 741
YU2 ---------------------------------------------------------------------- 742
BCSG3C --------------------------------------V------------------------------- 742
P896 -----------------------------------------------------------T---------- 740
VE1RT ------E------------------------------------ 560
VE2RT -N--------------------------------------R-- 560
VE3RT -N----------------------------------T------ 560
VE4RT -N---------------------------------------I- 560
VE5RT ------------------------------------S------ 560
VE6RT ------------------------------------------- 560
VE7RT -----------------------------------------I- 560
VE8RT ------------------------------------T---R-- 560
HX330BC -------------------------------------------------x 567
HX660BC -------------------------------------------------x 567
HXBCRT -N-----------------------------------------------x 567
PD165BC ------------------------------------------- 560
PD330BC ------------------------------------------- 560
PD495BC ------------------------------------------- 560
PD660BC ------------------------------------------- 560
PDBCRT ------------------------------------------- 560
3202A12 ---------------------------------------------------------------------- 742
3202A21 ---------------------------------------------------------------------- 742
MANC ---------------------------------------------------------------------- 742
PFA660 -N--------------------------------------------------D----------------- 587
PFA660AZT0 -N---------------------------------G------- 560
TH475A -N-----------I--------------------------------------D----------------- 742
C18MBC -N---------------------------------------I-----------G-------------G-- 754
ACH3202A12 ---------------------------------------------------------------------- 742
PDBC ------------------------------------------- 560
WR27 ------------------------------------S-------W--------D------------GE-- 742
RTPX -------------------------------------------------Q---D-- 573
WEAU160 ------------------------------------S--------------------------------- 742
CONSENSUS-C VNQIIEQLI?KERVYLSWVPAHKGIGGNEQVDKLVSSGIRKVLFLDGI?KAQEEHEKYHSNWRAMA?EFN 702
92BRO25 ---------K--------------------------------------N-----------------S--- 739
ETH2220 ---------S--------------------------------------D-----------------N--- 749
CONSENSUS-D VsQIIEQLIKKEKVYLAWVPAHKGIGGNEQVDKLVSQGIRKVLFLDGIDKAQEEHEKYHNNWRAMASDFN 739
ELI -N-------------------------------------------------------------------- 741
Z2Z6 ---------------------------------------------------------------------- 741
NDK ---------------------------------------------------------------------- 741
CONSENSUS-O VQQIIEELTKKE?VYLTWVPAHKGIGGNEKIDKLVSKDIRRVLFLEGIDQAQEDHEKYHSNW?ALAS?FG 668
ANT70 ------------Q-------------------------------------------------K----E-- 738
MVP5180 ------------R-------------------------------------------------R----D-- 738
CONSENSUS-A VNQIIEKLIEK?KVYLSWVPAHKGIGGNEQVDKLVSSGIRKVLFLDGIDKAQE?HE?YH?NWRAMASDFN 683
A/G_IBNG ---------K-D------------------------N----------------E--R--S--K------- 742
A/E_93TH253 -S----E--K-E-----------------------I------------N----E--R--S---T------ 734
A/E_CM240 ------E--K-E-----------------------------------------E--R--S---T------ 747
A/E_90CR102 -----------E-----------------------------------------D--R--S---------- 742
MAL ------Q--Q-D-----------------------------------------E--K--S---------- 741
CONSENSUS-CPZ V??II??LIK?E?IYLSWVPAHKGIGGNEQVDKLVS?GIR?VLFL?GID?AQE?H??YHSNW???A???N 509
CPZGAB -NQ--EE---K-K-----------------------A---K----D---R---E-ER-----KAM-SDF- 740
CPZANT -EE--QK---R-Q-----------------------Q---Q----E---K---D-DK-----RSL-DEY- 745
CONSENSUS-A LPP?VAKEIVASC?KCQLKGEAMHGQVDCSPGIWQLDCTHLEGKVILVAVHVASGY?EAEVIPAETGQET 750
92UG037 ---I---------D------------------------------------------V------------- 812
U455 ---V---------N------------------------------------------I------------- 811
CONSENSUS-B LPPvVAKEIVAsCdKCQLKGEAMHGQVDCSPGIWQLDCTHLEGK?ILVAVHVASGYIEAEVIPaETGQET 810
SF2 --------------------------------------------I------------------------- 812
LAI --------------------------------------------V------------------------- 824
HXB2R --------------------------------------------V------------------------- 812
NL43 --------------------------------------------V------------------------- 812
NY5CG --------------------------------------------V------------------------- 812
LW123 --------------------------------------------V------------------------- 812
MN ---I----------------------------------------V------------------------- 814
JRCSF ---I----------------------------------------I------------------------- 816
JRFL --------------------------------------------I------------------------- 812
OYI --------------------------------------------I------------------------- 812
CAM1 --------------------------------------------V------------------------- 812
HAN --------------------------------------------I------------------V------ 811
D31 --------------------------------------------V------------------------- 812
RF --------------------------------------------I------------------------- 811
YU2 --------------------------------------------V------------------------- 812
BCSG3C --------------------------------------------I------------------------- 812
P896 -------------N------------------------------V------------------------- 810
3202A12 --------------------------------------------I------------------------- 812
3202A21 --------------------------------------------I------------------------- 812
MANC --------------------------------------------V------------------------- 812
PFA660 --------------------------------------------V------------------------- 657
TH475A --------------------------------------------V------------------------- 812
C18MBC ---I----------------------------------------I------------------------- 824
ACH3202A12 --------------------------------------------I------------------------- 812
WR27 -----------C--------------------------------I------------------------- 812
WEAU160 --------------------------------------------I------------------------- 812
CONSENSUS-C ?PP?V?KEIVA?CDKCQLKGEA?HGQV?CSPGIWQLDCTHLEGKIILVAVHVASGYIEAEVIPAETGQET 766
92BRO25 L--I-A-----S----------T----D------------------------------------------ 809
ETH2220 I--V-P-----C----------I----N------------------------------------------ 819
CONSENSUS-D LPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQET 809
ELI ---------------------------------------------------------------------- 811
Z2Z6 ---------------------------------------------------------------------- 811
NDK ---------------------------------------------------------------------- 811
CONSENSUS-O LPP?VAKEIIASCPKCHIKGEA?HGQVD?SPE?WQ?DCTH?EGKIIIVAVHVAS?FIEAEVIPAETGQET 731
ANT70 ---V------------------I-----C---V--I----M-------------G--------------- 808
MVP5180 ---I------------------T-----Y---I--M----L-------------D--------------- 808
CONSENSUS-A LPP?VAKEIVASC?KCQLKGEAMHGQVDCSPGIWQLDCTHLEGKVILVAVHVASGY?EAEVIPAETGQET 750
A/G_IBNG ---I---------D---M-----------G--------------I-----------I------------- 812
A/E_93TH253 ---I-------N-D------------------------------------------I------------- 804
A/E_CM240 ---I------TN-D------------------------------------------I------------- 817
A/E_90CR102 ---I---------D------------------------------------------I------------- 812
MAL ---I---------D------------------------------I-I---------I------------- 811
CONSENSUS-CPZ LPPIVAKEI?A?CDKC?VKGEA?HGQVDCSPGIWQVDCTHLEGKVIIVAVHV?SG?IEAEV???ETG??T 568
CPZGAB ---------V-H----Q-----M-----------------------------A--Y-----IPA---QE- 810
CPZANT ---------I-Q----H-----R-----------------------------S--F-----MAD---KS- 815
CONSENSUS-A AYF?LKLAGRWPVKV?HTDNGSNFTSAAVKA?CWWAN??QEFGIPYNPQSQGVVESMNKELKKIIGQVRE 815
92UG037 ---L-----------V---------------A-----VK------------------------------- 882
U455 ---I-----------I---------------V-----IQ------------------------------- 881
CONSENSUS-B AYFlLKLAGRWPvktiHTDNGsNFtstTVkAACWWaGiKQEFGIPYNPQSQGVvESmNkeLKkIIGQVRD 880
SF2 ----------------------------------------------------------N----------- 882
LAI ---------------------------------------------------------------------- 894
HXB2R -------------------------GA--R---------------------------------------- 882
NL43 ---------------V-------------------------------------I---------------- 882
NY5CG ---------------V-------------------------------------I---------------- 882
LW123 --------------------------A------------------------------------------- 882
MN ---------------------P-------------T-----------------I---------------- 884
JRCSF -------------T-------------------------------------------------------- 886
JRFL ---------------------------------------------------------------------- 882
OYI ---I------------------------------------------------------N----------- 882
CAM1 ---------------------G--I---------------------------------N----------- 882
HAN ---------------V-----P------------------------------------------------ 881
D31 ---I---------------------------------V-------------------------------- 882
RF ---I----------V--------------------------------------------Q--Q------- 881
YU2 -------------T------------A------------------------------------------- 882
BCSG3C ---------------------------------------------------------------------- 882
P896 ---------------------------------------------------------------------- 880
3202A12 ---I---------T------------A------------------------------------------- 882
3202A21 ---I---------T------------A------------------------------------------- 882
MANC -------------T-------------------------------------------------------- 882
PFA660 ------------x 670
TH475A --------------------------A------------------------------------------- 882
C18MBC ---I---------N-------G--I---------------------------------R----------- 894
ACH3202A12 ---I---------T------------A------------------------------------------- 882
WR27 ---I--------------------I-------------------------------I------------- 882
WEAU160 ---I-------------------------------------------------I---------------- 882
CONSENSUS-C AYF?LKLAGRWPV?VIHTDNGSNF?SN?VKAACWWAGIQQEFGIPYNPQSQGVVESMNKELKKIIGQVR? 831
92BRO25 ---I---------K----------I--T-----------------------------------------D 879
ETH2220 ---L---------R----------T--A-----------------------------------------E 889
CONSENSUS-D AYFlLKLAGRWPVKvVHTDNGSNFTSAaVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRD 879
ELI ---------------------------------------------------------------------- 881
Z2Z6 ---I----------I------------------------------------------------------- 881
NDK ---------------------------T------------------------------------------ 881
CONSENSUS-O AYFLLKLAARWPVKVIHTDNGPNFTS??MKAACWW??IQHEFGIPYNPQSQGVVEAMNKELKSIIQQVRD 797
ANT70 --------------------------TT-------AN--------------------------------- 878
MVP5180 --------------------------AA-------TG--------------------------------- 878
CONSENSUS-A AYF?LKLAGRWPVKV?HTDNGSNFTSAAVKA?CWWAN??QEFGIPYNPQSQGVVESMNKELKKIIGQVRE 815
A/G_IBNG ---I-----------I---------------A-----VT------------------------------D 882
A/E_93TH253 ---L-----------I---------------A-----VR------------------------------- 874
A/E_CM240 ---L-----------I---------------A-----VQ------------------------------- 887
A/E_90CR102 ---L---------R-I---------------A-----VQ------------------------------- 882
MAL ---I-----------V---------------A-----IK------------------------------- 881
CONSENSUS-CPZ AYFLLKLA?RWPVKTIHTDNG?NFTSAAVKAACWWA?I?QEFGIPYNPQSQGVVES?NK?LK?IIGQ?RD 630
CPZGAB --------G------------P--------------D-K-----------------L--E--K----V-- 880
CPZANT --------S------------A--------------N-Q-----------------M--Q--Q----I-- 885
CONSENSUS-A QAEHLKTAVQMAVFIHNFKRKGGIGGYSAGERIIDIIA?D?QTKELQKQI?KIQ?FRV?YRDSRDPIWKG 880
92UG037 --------------------------------------S-L---------T---K---C----------- 952
U455 --------------------------------------T-I---------S---N---Y----------- 951
CONSENSUS-B QAEHLKtAVQMAVFIHNFKRKGGIGGYSAGeRIvdIIAtDIQtkeLQKQITkIQNfRVYYRDsrdPlWKG 950
SF2 --------------------------------------------------------------NK------ 952
LAI ---------------------------------------------------------------------- 964
HXB2R ----------------------------------------------------------------N----- 952
NL43 ------------------------------------------------------------------V--- 952
NY5CG ------------------------------------------I-----------------------V--- 952
LW123 ----------------------------------------------------------------N----- 952
MN ------R---------------------------G----------------------------------- 954
JRCSF ---------------------------------I----------------------------N---I--- 956
JRFL ----------------------------------------------------------------E----- 952
OYI ----------------------------------------------------------------E----- 952
CAM1 ---------------------------------I------------------------------------ 952
HAN ----------------------------------------------------------------E-F--- 951
D31 ---------------------------------------------------------------------- 952
RF ---------------------------------------------------------------------- 951
YU2 ---------------------------------------------------------------------- 952
BCSG3C --------------------------------------------------------------NK------ 952
P896 --------------------------------------S------------------------------- 950
3202A12 ---------------------------------------------------------------------- 952
3202A21 ---------------------------------------------------------------------- 952
MANC ------------------------------G---------------------------------N----- 952
TH475A ---------------------------------------------------------------------- 952
C18MBC ---------------------------------------------------------------------- 964
ACH3202A12 ---------------------------------------------------------------------- 952
WR27 ---------------------------------I-----------------I---S-------------- 952
WEAU160 ---------------------------------I---------QQ------------------------- 952
CONSENSUS-C QAEHLKTAVQMAVFIHNFKR?GG?G?YSAGERIIDIIA?DIQTKELQ?QI?KIQNFRVYYRDSRDPIWKG 895
92BRO25 --------------------K--L-#------------T--------K--M------------------- 948
ETH2220 --------------------R--I-G------------S--------N--L------------------- 959
CONSENSUS-D QAEHLKTAVQMAVFIHNFKRkgGIGGYSAGERIIDIIATDIQTkELQKQIiKIQNFRVYYRDSRDPIWKG 949
ELI --------------------RR------------------------------------------------ 951
Z2Z6 --------------------------------------------------T------------------- 951
NDK -------------------------------------------R-------------------------- 951
CONSENSUS-O QAEHL?TAVQMAVFVHNFKRKGGIGGYTAGER?IDILASQIQTTELQKQILKI??FRVYYRDSRDPIWKG 863
ANT70 -----R--------------------------I--------------------HK--------------- 948
MVP5180 -----K--------------------------L--------------------NN--------------- 948
CONSENSUS-A QAEHLKTAVQMAVFIHNFKRKGGIGGYSAGERIIDIIA?D?QTKELQKQI?KIQ?FRV?YRDSRDPIWKG 880
A/G_IBNG --------------------------------------S-I---------I---N---Y----------- 952
A/E_93TH253 --------------------------------------T-I---------T---N---Y----------- 944
A/E_CM240 --------------------------------------T-I---------T---N---Y----------- 957
A/E_90CR102 -------------------------E------------T-I---A-----T---N---Y----------- 952
MAL -----------------------------------M--T-I---------T---N---Y---N------- 951
CONSENSUS-CPZ QAE?LKTAV?MAV?IHNFKRKGGIGGYT?G?RI?DI?ATDIQT??LQ?QILK?Q?FRV?YRDSRDP?WKG 686
CPZGAB ---H-----Q---F--------------A-E--I--I------SE--K----V-K---Y-------I--- 950
CPZANT ---Q-----V---H--------------P-Q--L--L------TQ--N----I-Q---H-------V--- 955
vif cds ->
CONSENSUS-A PAKLLWKGEGAVVIQDNSDIKVVPRRK?KII?DYGKQMAGDDC?AGRQDEDx 929
92UG037 ---------------------------V---K-----------V-------- 1004
U455 ---------------------------A---R-----------M------- 1002
CONSENSUS-B pakllwkGEGAVVIQDNsdIKVVPRRKaKiIRDYGKQmagDDCVAsRQDED? 1001
SF2 --------------------------------------------------- 1003
LAI --------------------------------------------------- 1015
HXB2R --------------------------------------------------- 1003
NL43 --------------------------------------------------- 1003
NY5CG --------------------------------------------------- 1003
LW123 --------------------------------------------------- 1003
MN -----------------N-----------V-------T------------- 1005
JRCSF ---------------------------V----------------------- 1007
JRFL ---------------------------V----------------------- 1003
OYI --------------------------------------------------- 1003
CAM1 --------------------------------------------------- 1003
HAN --------------------------------------GS----------- 1002
D31 ------------------E--------------------------G----- 1003
RF H-------------------------------------------------- 1002
YU2 ---------------------------------------------G----- 1003
BCSG3C --------------------------------------------------- 1003
P896 --------------------------------------------------- 1001
3202A12 ---------------------------------------------------$ 1003
3202A21 ---------------------------------------------------$ 1003
MANC ------------------E--------V-----------------G----- 1003
TH475A ---------------------------------------------------x 1004
C18MBC ---------------------------V-----------------------x 1016
ACH3202A12 ---------------------------------------------------x 1004
WR27 ---------------------------------------------------x 1004
3799(12-88) .......--------------------V-----------------------x 45
CNTRL1.1 .......--------------------V-----------------------x 45
3799(9-93) .......--------------------V-----------------------x 45
WEAU160 ---------------------------------------------------$ 1003
CONSENSUS-C PAKLLWKGEGAVV?QDNSDIKVVPRRK?KII?DYGKQMAGADC?A?RQDEDx 942
92BRO25 -------------L-------------V---K-----------M-S------ 1000
ETH2220 -------------I-------------A---R-----------V-G------ 1011
CONSENSUS-D PAKLLWKGEGAVVIQDnSDIKVVPRRKVKIIRDYGKQMAGDDCVASRQDED 1000
ELI ----------------K---------------------------------- 1002
Z2Z6 --------------------------------------------------- 1002
NDK --------------------------------------------------- 1002
CONSENSUS-O PAQLLWKGEGAVVIQDKGDIKVVPRRKAKIIR?YGKQMAGTDSMA??QTESES?EQP?EIP 919
ANT70 --------------------------------E------------SG------V---S--- 1009
MVP5180 --------------------------------D------------NR------M---G--- 1009
CONSENSUS-A PAKLLWKGEGAVVIQDNSDIKVVPRRK?KII?DYGKQMAGDDC?AGRQDEDx 929
A/G_IBNG ---------------------------A---R-----------V------- 1003
A/E_93TH253 ---------------------------A---R-----------V-------- 996
A/E_CM240 ---------------------------A---R-----------V-------- 1009
A/E_90CR102 ---------------------------A---R-----------V----N--- 1004
MAL ---------------------------A---R-----------V--G---- 1002
CONSENSUS-CPZ PA?LLWKGEGAVVI?DQGELKVVPRRKAKIIRDYGKQMAGDDCVASRQNED 735
CPZGAB --T-----------Q------------------------------------ 1001
CPZANT --Q-----------x 970